Looks like the Highlander was built in Japan through the 2009 model year for the regular model, a mix of Japan and US built ones for model year 2010, and all USA (Indiana; not Ohio, that's Honda) after that. The Hybrids continued to be built in Japan until the 2013 model year, for my 2014+ they were made in Indiana.

As far as Origin, looks like the latest model (2014+, XU50) was designed in the US, and is no longer made in Japan.

http://www.adandp.media/articles/2014-toyota-highlander-improvement-through-engineering